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MASH/NAFLD: Given the liver fat-reducing effects of GLP-1 receptor agonism, orforglipron may be evaluated for metabolic dysfunction-associated steatohepatitis (MASH), a condition affecting an estimated 5-6% of the adult population for which effective oral therapies are urgently needed

Many experiments assess immediate effects within days to weeks post-administration

Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) represent unique cases of infection-triggered brain autoimmunity

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Further research is needed to reveal the exact metabolic functions of GST isoenzymes in infected plants and to understand their contribution to disease resistance