Converging evidence suggests that reductions in cerebral blood flow (CBF) and cerebrovascular dysfunction may precede structural and functional deficits associated with neurodegeneration, representing one of the earliest indicators of ADRD risk (Jack et al., 2010), and therefore, cerebrovascular dysfunction may serve as an ideal early-stage biomarker that is receptive to aerobic exercise interventions (Kleinloog et al., 2019
"Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial." The Lancet Diabetes & Endocrinology
Assessment It is suggested that at an initial appointment details of any pigmented or solitary lesion arising on the feet is recorded in the patient's notes with a description including location, size, colour and shape
This usually resolves within minutes
This complication was much more common with phenformin therapy, the initial biguanide, and the risk with metformin is estimated to be 20 times less (53)
10.1038/s41467-020-18414-8 Nat Commun
