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Neither the Summary of Product Characteristics (SmPC) for Rybelsus nor major drug interaction databases identify ibuprofen as a contraindicated or significantly interacting medication

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"Our findings about the real-world use patterns of these medications and associated clinical outcomes could inform the decisions of health care providers and their patients on the role of treatment discontinuation and maintenance dosage in achieving clinically meaningful weight reductions," Gasoyan said

Biochemical and biophysical research communications 440 , 570575, (2013)

PMID: 21194578

Tirzepatide showed no significant differences in surgery rates when compared with other agents: Naltrexone/Bupropion (HR 0.81, 95% CI 0.631.05, p = 0.11), Phentermine/Topiramate (HR 0.43, 95% CI 0.082.23, p = 0.30), or Phentermine (HR 3.21, 95% CI 0.6116.91, p = 0.15)