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Patients regained weight by half roughly every 23 weeks, with broadly similar modeled trajectories across different GLP-1RAs

Clinical trial data supports long-term GLP-1 therapy for most patients with obesity, as discontinuation causes substantial regain even with lifestyle changes

Moreover, mtDNA copy number and mitochondrial-related gene expression were enhanced in the WAT of exenatide-treated mice

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Scaled for a human body, this would translate to roughly 140 micrograms per injection with treatments administered over 10 days