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The only cross-compound evidence that exists is indirect : network meta-analyses that statistically connect drugs through their shared comparators (usually placebo) rather than through direct comparison

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Furthermore, the model can be extended, in particular by using multi-omics approaches, such as metabolomics of the bacterial consortium and transcriptomics of the respective immune cells, providing mechanistic insights into the chemical-microbiome-immune interaction triangle

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Seimon, R

Most of the clinical research has been conducted in rodent models, with a few human studies here and there