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Significant weight loss isnt always a benefit for older adults, especially if it means the loss of bone and muscle mass, which are critical for good physical health

However, it is critical to recognise that these direct mechanisms are considered secondary, and in some cases remain controversial, compared with the proven impact of indirect pathways

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a promising therapeutic option for people with arthritis and obesity or type 2 diabetes mellitus owing to their pleiotropic effects, including weight loss, improved survival and reduced risk of major cardiovascular and renal events

A 150,000-household study found grocery spend down about 5 percent within six months of starting, and more than 8 percent for higher earners

Diabetes Obes Metab 24(1):94105 Zaazouee MS et al (2022) Semaglutide for the treatment of type 2 Diabetes Mellitus: A systematic review and network meta-analysis of safety and efficacy outcomes

Thus, although notable advancements have been made in scaling current production processes, industrial investments into novel biopharmaceutical strategies are urgently needed