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long-term toxicity in humans remains an unknown

Chemical Reviews

They observe that their dogs' energy levels immediately are much higher, that their respiratory rates have dropped from the high 20s and 30s per minute down to the mid-teens, and that their cardiac coughs have diminished -- a sign that the dogs' left atriums may had shrunk

The only notable exception is the observation made by Newson and colleagues in 1979 56 , where an image of (only) one putative synapse with a gut endocrine cell was provided