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To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Han et al., 2009

Hydrating ingredients also play a key role in minimizing the appearance of fine lines

10.1097/01.LAB.0000098428.51765.83 24

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Where bacteriostatic water contains a bacteriostatic preservative to prevent microbial contamination over time, sterile water is free from preservatives and additives