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Both peptides may be prohibited by various athletic organizations including the World Anti-Doping Agency (WADA), and their use could result in sanctions, disqualification, or other penalties for competitive athletes

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10.1164/rccm.201305-0908LE Am J Respir Crit Care Med

This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

The one human knee study, Lee et al