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These changes generate a systemic and local milieu rich in metabolic substrates, hormones, and proinflammatory cytokines that fuel tumour growth

Moreover, its therapeutic potential may extend to injury-related conditions, such as stress fractures, by facilitating skeletal repair and recovery

FAK-paxillin signaling and cell migration Focal Adhesion Kinase (FAK) and paxillin are key regulators of cell migration, the process by which repair cells move to injury sites

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Most current clinical use involves autologous MSCs harvested from the patient (usually from bone marrow or adipose tissue) and delivered either to specific sites of injury or systemically