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The improvement effect of semaglutide on obese mice is partially driven by changes in serum metabolism and gut microbiota, as confirmed by fecal transplant experiments in this study

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Special Considerations Sensitive Skin: Although gentler than many anti-aging actives, individuals with very sensitive skin or conditions like rosacea should begin with the lowest possible concentration and closely monitor their skins response

10.1016/S0140-6736(19)31149-3 36 GersteinH

PCOS patients should also be screened for thyroid history before starting, as semaglutide is not advised with personal or family history of medullary thyroid carcinoma