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"It's important if somebody does start experiencing some new symptoms of any kind on these medications, we have to remember we don't have very long-term data on these meds, so there are still a lot of unknown risks with these medications," Parrella said

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In hepatocarcinogenesis, aflatoxin B1 (AFB1) exposure primarily induces oxidative stress through CYP3A4-mediated metabolic activation, generating ROS and MDA that directly cause DNA damage [389, 390]

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