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The extracellular matrix, the structural scaffold beneath the skins surface, needs to be actively rebuilt rather than left to passively contract

Journal of andrology

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In human Phase 2 clinical trials, doses ranged from 0.3 to 4.5 mg administered once weekly

Their meta-analysis pooled data from multiple clinical trials and used multivariable linear regression a statistical method that controls for confounding variables to extract the clearest possible signal from the noise