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The topic modeling themes were generated by combining Non-Negative Matrix Factorization (NMF) and an LLM, in this case, GPT-4o, to identify key topics within the data

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However, the clinical translation of Kla-targeted therapies faces notable challenges, including the lack of specific inhibitors, potential off-target effects and the complex tissue-specific functions of lactylation

Cardiovascular risk : If you have established cardiovascular disease or high cardiovascular risk, your clinician may favour agents with proven cardiovascular benefits in outcome trials, such as semaglutide, liraglutide, or dulaglutide

It works by boosting the production of proteins like collagen and elastin, which are important components for healthy skin