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A 2022 systematic review examining antioxidant interventions for liver disease concluded that NAC showed "moderate to strong evidence" for improving liver function markers, while oral glutathione (non-liposomal forms) had "limited evidence" of clinical efficacy

10.1038/s41423-021-00740-6 46 IannuzziJ

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This suggests that metformin has an antitumor effect by alleviating immunosuppression and promoting T cell-mediated immune response

Moreover, COX-2 inhibitors can cause metabolic imbalances that result in over production of two toxic cytokines, tumor necrosis factor alpha (TNF-) and interleukin 1 beta (IL-1) (Takahashi 1998