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This is the opposite of the intended therapeutic effect

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PE-22-28 was specifically designed for improved stability over spadin, with a duration of action of approximately 23 hours compared to spadin's 7 hours

doi: 10.1007/s10735-009-9218-1

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Ultra-high IV doses of methyl B12 (25mg) were shown safe and potentially effective for patients with peripheral neuropathy and chronic axonal degeneration