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Fluvoxamine but not citalopram increases serum melatonin in healthy subjects-an indication that cytochrome P450 CYP1A2 is involved in melatonin metabolism in man

While the early years focused attention on the catalytic properties of isozymes and their organ distribution, subsequent publications have served to exemplify their ligand binding properties, influence on cell signaling, thioltransferase activities and their general involvement in human pathologies

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No large-scale trial has tested it

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