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[90] Endocrine effects may include suppression of the hypothalamic-pituitary-adrenal axis, which could lead to adrenal insufficiency if therapy is discontinued abruptly

FXR-deficiency induces nonalcoholic steatohepatitis in LDLR/ mice fed a high-fat diet

Gradual escalation helps the body adjust and may reduce digestive side effects

Softtissue and bony deficiencies are variable with accompanying nasal distortion (Figure 1)

Thus, Ozempic represents a shift towards more integrated, holistic management of diabetes, addressing multiple aspects of the disease beyond just glucose control