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However, the in vivo potency was lower than that of topiroxostat, which could be explained by the poor absorption found in the parallel artificial membrane permeability assay [77]

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Recent investigations utilizing Caco-2 cell models have shown that Bifidobacterium lactis upregulates cyclooxygenase-1 (Cox-1) and downregulates Cox-2 gene expression (183)

This powerful combination demonstrates synergistic effects, bolstering CD4 + T and CD8 + T cells infiltration and significantly impeding the progression of tumors