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A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population

Proposed Mechanisms (Preclinical) Incretin & Glucose Control Activates GLP-1 receptors on pancreatic -cells to enhance glucose-dependent insulin secretion

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It acts directly on neighboring -cells to inhibit the secretion of glucagon and can also indirectly influence -cells by inhibiting the secretion of other hormones.243 In the local islet environment, a high concentration of somatostatin creates an inhibitory milieu, further reducing the activity of -cells and the secretion of glucagon.244 Additionally, somatostatin can inhibit gastrointestinal activity, reducing the secretion of pancreatic enzymes and gastric acid, thereby indirectly decreasing the demand for glucagon.245,246 Hence, GLP-1 activates -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion

Lojo et al., 2016

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