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A study showed that copper ions themselves can inhibit 5-reductase, raising the question: could applying or injecting GHK-Cu meaningfully lower DHT, locally or even systemically

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In addition, the immunogenicity of biologics is a major challenge affecting drug efficacy and safety

2025;13:e18924

As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]