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Are there any topical treatments available for melasma caused by B12 deficiency

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Others might notice transient dizziness or light-headedness shortly following an injection

Yes, some patients experience temporary fatigue as their body adjusts to therapeutic B12 doses and metabolic processes reactivate

However, the further clinical development of pramlintide/metreleptin combination therapy has been discontinued by the manufacturing companies because of safety concerns [249](Table 3 )