Financial support and sponsorship This work was supported by Fondo de Investigacin Sanitaria-FEDER (PI25/00528) and CIBEROBN from the Spanish Instituto de Salud Carlos III, and the Department of Health of the Gobierno de Navarra (GN2025/52)
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This covalently-binding estrogen metabolite has positive effects in cell proliferation and has even been used to treat certain cancers, but it can cause an existing cancerous tumor or damaged estrogen-sensitive tissue to grow aggressively as well
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