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The insulinotropic effect of GLP-1 on cells is due primarily to GLP-1 receptormediated augmentation of GSIS

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Given the strong female predominance of AITD and the midlife rise in metabolic risk during the menopausal transition, targeted trials in perimenopausal and postmenopausal women are warranted, with attention to hormone status, body-composition change, cardiovascular risk, and dose adjustments of thyroid medications during weight loss [1,2,66] (Figure 2)

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The exact number depends on your starting skin tone, desired results, dosage used, and individual response to treatment