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Elazar et al., 2009)

Moreover, compensatory activation of IGF-IR is involved in resistance to co-inhibition of EGFR and MEK in KRAS-mutated colorectal cancer cells [120]

Liang L, Yang B, Jiang N, Fu W, He X, Zhou Y, et al

While the cataract phenotype observed here was different to that observed in humans, these results confirmed that long-term in vivo exposure to UV-A light leads to cataract in an albino mouse model

These lipid intermediates act as activators of PKC, which in turn dephosphorylates AKT and disrupts insulin signaling and thus leads to insulin resistance (130, 131)

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