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ZD: In the past 3 years, ZD received speaker or consultant honoraria and/or served on advisory boards at: Antabio, Foresee Pharmaceuticals, GlaxoSmithKline, Hippo-Dx, QPS-Netherlands, Sanofi-Genzyme-Regeneron, and Springer Media all outside the submitted work

Because tirzepatide's primary action occurs through neurohormonal signaling rather than direct enzyme activation, it operates on a different level than berberine's AMPK-mediated effects

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Testing these hypotheses merits future effort, as does reconsideration of the previous literature that has shown positive attributes of GIPR agonism for beta cell function 10,42,43

However, this is something you should speak to your provider about and see what all the options are

10.1016/s0140-6736(70)91347-4 Lancet 177 StinsonL