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Co-activation of both pathways simultaneously produces convergent signal amplification a superadditive GH release response that substantially exceeds the sum of the individual peptide responses and underlies the rationale for the dual-peptide combination format in GH axis research

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Ferr S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueo J, Gutirrez MA, et al

Spanhel, L., Haase, M., Weller, H

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These results highlight a substantial translational gap, indicating that the metabolic deterioration linked to early-stage AD may not be reversible with existing dosages or intervention schedules