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Nat Clin Pract Endocrinol Metab (2005) 1:2231

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These drugs are given to people at a high risk of getting blood clots such as those with atrial fibrillation, a type of heart arrhythmia

Both classes are resistant to the enzymatic degradation seen for native GLP-1, which is cleaved by the DPP-IV enzyme to generate inactive metabolites and intact GLP-1 forms with low affinity for the GLP-1R

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