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This imbalance can happen due to any of the above-mentioned factors

Broster said peptide programmes required orthogonal, structure-informing analytics, particularly high-resolution accurate-mass mass spectrometry coupled with ultra-high-performance liquid chromatography, to resolve, assign and track variants with confidence

Nevertheless, although off-target inhibition of DPP-9 could be one potential explanation for the association between saxagliptin and heart failure in an experimental setting, it is uncertain whether mean exposure levels of saxagliptin reach a high enough level to affect DPP-9 activity when used at its therapeutic dose in humans

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However, such patients are often older and therefore likely to have some degree of vascular insufficiency, which may be apparent on a brain scan

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