Studies in mice, rats, rabbits, and dogs found no severe toxic effects across a wide dose range from 6mcg/kg to 20mg/kg
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If a prescriber determines the benefit justifies the risk in a specific case, the lowest available dose (0.5 mg) should be used no more than twice weekly, with biweekly copper monitoring and a predefined stopping rule
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therefore, arginine dystrophy is also present
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