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GLP attenuates HSC activation, collagen deposition, and -SMA expression by suppressing TGF-/Smad and TLR4/NF-B signaling, modulating ECMreceptor interactions via downregulation of integrins (e.g., ITGA6, ITGA8), and influencing apoptosis and cell cycle regulators

In healthy rats, PIC treatment increased collagen synthesis 9-fold compared to the control group

Within the cell, it exists mainly (98%) in the thiol-reduced form (GSH), but some are also present as glutathione disulfide (GSSG)

NNMT-mediated CD44 mRNA m6A methylation produces a CD44v3 splice variant, while MNA stabilizes CD44 protein by inhibiting the ubiquitin-mediated degradation

Diabesity is a complex, multifactorial condition that poses significant health risks, including cardiovascular disease, diabetes, and certain cancers

[DOI] [Google Scholar] 79.Kammoun M., Miladi S., Ali Y.B., Damak M., Gargouri Y., Bezzine S