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Proceedings of the National Academy of Sciences of the United States of America , doi:10.1073/pnas.1513004112 (2015)

Importantly, these mechanistic hypotheses are supported by evidence from large, randomised controlled trials, which has demonstrated that GLP-1RAs reduced major adverse cardiovascular events (MACE), including myocardial infarction, stroke and cardiovascular death, particularly in high-risk individuals such as those with type 2 diabetes mellitus

Q5: Is TMAO routinely included in metabolomics studies

Cold-chain integrity, consistent supply availability, and digital support for adherence and refill management have become critical differentiators as therapies scale into direct-to-patient delivery models