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By mimicking these hormones, the medication helps the pancreas release the right amount of insulin, slows down how quickly the stomach empties, and signals to the brain that you are full

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That means orforglipron primarily works when blood sugar is elevated

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Michael Ganio, senior director of pharmacy practice and quality at the American Society of Health-System Pharmacists, a group that tracks drug shortages in the U.S., said the group is still hearing reports from patients and caregivers suggesting tirzepatide continues to be hard to come by