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Isoiquiritin apioside, an important component of Glycyrrhizae radix et rhizoma , could inhibit the upregulation of HIF-1 and HO-1 protein in lung tissue, downregulate the levels of PTGS2 and ACSL4, inhibit the ferroptosis in lung tissue of mice, and prevent intestinal I/ R-induced lung injury

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In melanocytes, MC1R activation can shift pigment production toward eumelanin, the darker pigment associated with greater UV absorption than pheomelanin

In lights of differential immune response in those infected with other SARS-CoV-2 viral variants (e.g

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