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Compared to metformin, they found no significant differences, except a significant decrease in HOMA-IR in the myoinositol group [6]

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Additionally, while clinical guidelines for indicated use of GLP-1 RAs are rapidly changing as evidence for GLP-1 RA use evolves, the ethics of off-label use are particularly important to consider given the impact these shortages can have on access for patients who otherwise have a strong clinical indication to be on them

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