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GLP-1s promote weight loss in several ways: Appetite suppression : GLP-1s act on the parts of the brain that control your appetite (satiety centers), reducing hunger and even thoughts and cravings for food Slowed stomach emptying : By keeping food in your stomach longer, GLP-1s make you feel full for a longer period after you eat Improved insulin function : GLP-1s help reduce the insulin spikes that promote storing fat and lead to increased appetite What Happens When You Stop a GLP-1