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Metabolomic analyses conducted by Jose et al

Over time, they can release inflammatory signals (often called the SASP, or senescence-associated secretory phenotype) that may contribute to tissue dysfunction seen with aging and some age-related conditions

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The long-term weight management picture has one part that doesn't make it into most ads: stopping GLP-1 therapy is consistently associated with weight regain in clinical extension studies

10.1038/nature01511 8 AgarwalA.RaiS

The four key mechanisms: Brain appetite centers: Reduces food noise the constant mental preoccupation with food and cravings that many patients describe as their biggest challenge Gastric emptying: Slows how quickly food leaves the stomach, producing prolonged fullness after smaller meals Insulin response: Stimulates insulin release when blood sugar rises improving glucose management without causing low blood sugar on its own Glucagon suppression: Reduces glucagon, a hormone that signals the liver to release stored sugar unnecessarily 2