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5.1.15 Other topical agents Other topical agents including thiamidol, linoleic acid, phytic acid, yeast extract, mulberry extract, rucinol, undecylenoyl phenylalanine, and epidermal growth factors have been reported in previous studies as effective compounds in melasma management (Lee et al., 2002

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These include impacts on heart rate and rhythm, electrolyte balance, blood pressure, pre-existing heart conditions, and interactions with other medications