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These secondary mechanisms are distinct from direct pharmacological effects

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It also restores replicative vitality to fibroblasts after radiation therapy

Combining 2 to 3 grams of each at lower individual doses may provide both immediate arginine availability and sustained replenishment through the citrulline-to-arginine conversion pathway

some neuroendocrine tumors may produce substances that induce diarrhea (i.e., carcinoid syndrome due to serotonin production)

Finally, the biggest risk is for people who have pernicious anemia, a rare condition in which a person is unable to absorb any B12 through their stomach or intestines people with this condition are the ones who actually need B12 injections