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In this systematic review, the authors conducted a comprehensive analysis of clinical trials to determine the impact of GLP-1 receptor agonists in reducing substance use disorder in patients

As established earlier, estrogen withdrawal creates a measurable energetic deficit in the brain, impairing the ability of neurons to efficiently utilize glucose and leaving them increasingly vulnerable to oxidative stress and metabolic dysfunction

doi: 10.1016/s0024-3205(99)00314-8

The FDA prescribing information for semaglutide and tirzepatide also carries a thyroid C-cell tumor warning from animal studies - the human relevance hasn't been established, but it's why patients with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome aren't candidates

Headaches and Injection Site Reactions Headaches and injection site reactions, including mild redness or irritation at the weekly injection site, were also documented in trial participants, though these were less commonly reported than gastrointestinal symptoms

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