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Gastrointestinal events were the most common side effects, and discontinuation due to adverse events occurred more often in retatrutide groups than in placebo

Most patients begin with a foundational regimen designed to stabilize mast cells and block mediator effects

Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial

Wu Q, Huang F

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