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GSSG needs to be reduced to GSH to have physiological activity

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Delivery, and especially Controlled Release of Antioxidants : Traditional drug delivery systems do not provide a prolonged beneficial antioxidant effect of the drugs, which in nanoparticle-based systems can be precisely controlled for release [17]

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An initial pilot study showed that supplementation of children with autistic disorder with 800 g folinic acid and 1,000 g betaine per day for two months normalised homocysteine levels and improved GSH:GSSG [46]

Mechanisms That Link Gut Dysbiosis to ME/CFS Pathogenesis A potential link between the pathophysiology of ME/CFS and alterations in the gut microbiome can be based on the communication that exists between the GI tract and the CNS [61]