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In many clinical trials of therapies for NASH, the majority of subjects have diabetes and, given published experience with BBR showing improvement in glycemic control, it was felt that BUDCA was more likely to exert positive metabolic effects 14,15

GI side effects at higher sublingual doses are still generally milder than at equivalent injectable doses because the daily peak concentration is lower

G., Ghigiarelli, J

Concentration: Typically 1 unit/mL in 0.9% normal saline (e.g., 100 units in 100 mL NS)

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It may also reduce the formation of toxic protein aggregates, which play a role in neurodegeneration