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In conclusion, we found that l-valine is a powerful stimulator of GLP-1 secretion both in rats and mice (ex vivo and in vivo), and we suggest a mechanism for l-valine stimulated GLP-1 release involving intracellular metabolism of the amino acid, leading to the closure of K ATP -channels, membrane depolarization and activation of V-gated Ca 2+ -channels (Fig

Glucagon-like peptide 1 (GLP-1) receptor agonist, treatment for type 2 diabetes

to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease

Provided as lyophilized powder requiring reconstitution with bacteriostatic water

Results develop progressively and may last up to two years or longer in some patients