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The evidence indicates that intensive glucose control significantly prevents DPN in T1D but has limited effectiveness in T2D, reasons for this could be that T1D DPN is characterized by more severe structural degenerative changes, progressive axonal atrophy, and paranodal degenerative changes or maybe the difference could be caused owing to different susceptibility of nerve fibers to hyperglycemic damage between the two diabetes types

However, complete diabetes management, which includes routine eye exams and control of other risk factors, such as hypertension and hyperlipidemia, is necessary to prevent diabetes-related blindness

Taquet M, Skorniewska Z, Hampshire A, Chalmers JD, Ho LP, Horsley A, et al

Melatonin increased superoxide dismutase in nine studies, glutathione peroxidase in seven studies, and catalase in five studies

Are serum uric acid levels predictors of cardiovascular risk

Sweeney, Kaitlin M1