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The obesity epidemic is a major public health issue that has escalated over many decades

Individual results vary based on starting weight, dose, response, and lifestyle alongside the medication

Notably, these benefits were observed regardless of participants' baseline weight or the amount of weight lost during the study . Oral Semaglutide Cardiovascular Outcomes: A study presented at the American College of Cardiology's Annual Scientific Session found that oral Semaglutide reduced the risk of cardiovascular death, heart attack, or stroke by 14% over four years

Ann N Y AcadSci 2002

She might be better served by not taking HRT, but rather one of the hormonal birth control methods which is what The Menopause Society would recommend

In August 2025, the Food and Drug Administration (FDA) also approved semaglutide for the treatment of MASH with moderate or advanced fibrosis [14] based on the results of a published trial [15]