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Bioavailability Topical GHK-Cu achieves good local bioavailability in the skin but minimal systemic absorption

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In the IMQ-induced murine model, topically applied OA-NPs@OA demonstrated superior transdermal penetration with sustained lesional retention, effectively reversing psoriatic phenotypes with remarkably reduced PASI scores and splenomegaly, normalized epidermal thickness, and suppressed immune inflammation and cytokines

Evid Based Complement Alternat Med (2014) 2014:289264