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In addition to intracellular effects, itaconate is secreted from activated macrophages, particularly within the tumor microenvironment, where it exerts numerous additional effects

A review in PMC reported that higher GGT was linked with a 100% increased risk of all-cause mortality in high-risk groups, a 130% higher risk for cancer mortality, and a 60% higher risk for vascular and ischaemic heart disease over 19 years of follow-up (PMC review on GGT and cardiometabolic risk)

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Potential symptoms may include: Patients experiencing persistent symptoms should consult their healthcare provider to determine whether dosage adjustments, medication interactions, or unrelated health issues may be contributing factors