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Orforglipron was also associated with a greater increase in heartrate than semaglutide

Plus, their fiber is harder to break down, so they travel all the way through the GI tract, reaching the large intestine where gut bacteria feed on it, producing compounds called short-chain fatty acids, which also produce GLP-1, notes Younkin

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Q: Should I inject tirzepatide in the abdomen if I'm experiencing a lot of nausea

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Why Stomach Cramps Happen When Starting Tirzepatide Your gastrointestinal tract contains millions of receptor cells that communicate with your brain about hunger, fullness, and digestive movement