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Injection site reactions typically clear within 24-48 hours

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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

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I am a somewhat regular user and usually will use for 2 months and then cycle off for a month or the results I see seem to diminish

PMID 18779510